Hans C.P., Chaudhary D.P., Bansal D.D. The incidence of diabetes was lower in the rats treated with metavanadate than in the control group, but this difference was not statistically significant. Moreover, focus is placed on: (a) interactions of V with the components of the spindle [123], (b) intercalation with DNA [33] (Fig. Bodua A., Wdowczyk M., Adamiec R. Rola biakowej fosfatazy tyrozynowej 1B (PTP-1B) w rozwoju insulinoopornoci. Influence of vanadium on serum lipid and lipoprotein profiles: a population-based study among vanadium exposed workers. Bis(maltolato)oxovanadium(IV) inhibits the activity of PTP-1B in Zucker rat skeletal muscle in vivo. In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. 317345. The creatinine clearance was also found to be lowered in the V-supplied rats [183]. and transmitted securely. Moreover, considering the well-known pro-oxidant properties of V, the fact that the increased generation of ROS and oxidative stress play a crucial role in V-induced toxicity, and the suggestions of other authors that the hepatotoxic, nephrotoxic, cardiotoxic, genotoxic, neurotoxic, and carcinogenic effects of this metal as well as inflammatory and fibrotic changes in the lungs are associated with its redox-active nature and ability to intensify LPO (see Fig. Zaporowska H., cibior A. Hematological effects of vanadium on living organisms. Zaporowska H., Wasilewski W. Wpyw wanadu na ukad krwiotwrczy i wybrane wskaniki krwi obwodowej szczurw szczepu Wistar. Sanna D., Serra M., Micera G., Garribba E. Interaction of antidiabetic vanadium compounds with hemoglobin and red blood cells and their distribution between plasma and erythrocytes. Moreover, the mechanisms of transport of V to target organs and its uptake by cells as well as the in vivo form of this metal and its influence on the immune system deserve further exploration (Fig. It is estimated that about 1% of intracellular VO2+ occurs in an unbound form [5]. Metavanadate - definition of Metavanadate by The Free Dictionary Thus, the toxicity of V that could derive from the chronic treatment with this element is of particular concern. cibior A. 19 A decrease in INS-R was demonstrated in obese rats (fa/fa Zucker rats) receiving V in the form of an organic derivative BMOV for 6 weeks [230] and in hypertensive rats chronically treated with VOSO4 [209]. Based on available literature data cited in section 8.2.2.9. PWN; Warszawa: 2013. Sobociska M., Kamysz E. Potencjalne zastosowanie enkefalin w diagnostyce i terapii rnych chorb. This aspect is also important in the context of occupational exposure and growing environmental pollution with V. The results of studies conducted in a rodent model by cibior et al. The authors revealed the existence of interplay or other interactions between both elements in diabetic rats. Younes M., Strubelt O. Vanadate-induced toxicity towards isolated perfused rat livers: the role of lipid peroxidation. Druga Twarz Tlenu. Yoffa W., Hurlich A. Watertown Arsenal Laboratory; 1945. [167], who demonstrated their promising in vitro efficacy against HT-29, OVCAR-3, A2780, A2780cis, and A2780adr cells. In turn, a decrease in the level of triglycerides (TG) in the blood was found: (a) in obese rats (fa/fa Zucker rats) receiving Na3VO4 (0.8 mg/mL) in drinking water for 4 months [239], (b) in obese non-diabetic Zucker fatty rats (ZF) and diabetic Zucker fatty rats (ZDF) after administration of organic (maltolic) vanadium derivatives, i.e. Metallurgical Examination of Armor and Welded Joints From the Side of a German PzKw V (Panther) Tank; pp. Barbagallo M., Dominguez L.J. The use of this metal in medicine is of particular concern. Sodium chloride was included as it is known to reduce vanadium 11) [127], which is a virulence factor most commonly secreted by Leishmania during growth [128], and (d) activation of macrophage/Th1-type response with the release of ROS and pro-inflammatory cytokines (including IL-1 and IL-6) [129] capable of destroying intracellular pathogens [147] (activity against Leishmania). Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Veiga C., Davim J.P., Loureiro A.J.R. Vanadium has been shown to be beneficial in the oral treatment of animal models of type 1 and type 2 diabetes. 18. Diabetes Several animal studies and a few small human studies suggest that vanadium may lower blood sugar levels and improve sensitivity to insulin in people with type 2 diabetes. it participates in the metabolism of lipids and lipoproteins [237]. Rybakowska I., Stpiska M., Sein Anand J., Patock M. Korzystny i niekorzystny wpyw zwizkw wanadu. V: vanadium, GLU: glucose. Oral administration of vanadate normalizes blood glucose levels in Some V compounds/complexes have been found to be promising for potential therapeutic use. 2009. [52] demonstrated a markedly reduced level of LPO in the bone of healthy rats supplemented with Mg (as MS) during the 12-week SMV exposure (0.125 mg V/mL). In higher concentrations, V can also act as a pro-apoptotic factor (by induction of oxidative stress) and lead to programmed cell death (apoptosis) with damage to mitochondrial membranes, cytochrome c (cyt c) outflow, and activation of caspases and poly (ADP-ribose) polymerase (PARP) [5] (Fig. Aldini G., Altomare A., Baron G., Vistoli G., Carini M., Borsani L., Sergio F. N-acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions. Eichstaedt I. Wiedza Powszechna; Warszawa: 1970. McCracken M. Dental implant materials: commercially pure titanium and titanium alloys. EPA United States Environmental Protection Agency . Long-term efficacy and safety of vanadium in the treatment of type 1 diabetes. Cunha-de Padua M.M., Suter Correia Cadena S.M., de Oliveira Petkowicz C.L., Martinez G.R., Merlin Rocha M.E., Merc A.L.R., Noleto G.R. Sanna D., Micera G., Garribba E. Interaction of VO. Generic Name Sodium metavanadate DrugBank Accession Number DB14702 Background Not Available Type Small Molecule Groups Approved, Experimental Structure Download Similar Structures Weight Average: 121.9295 Monoisotopic: 121.918477216 Chemical Formula NaO 3 V Synonyms Sodium trioxovanadate Sodium vanadate Sodium vanadate (V) Sodium vanadium oxide Moreover, there have also been reports on the effect of V administered as BMOV on bioavailability, biochemical parameters in serum, excretion and content of V and Mg in certain internal organs/tissues of healthy rats receiving V-containing feed and varying levels of Mg (magnesium oxide, MgO) [94], and the effect of V (BMOV) on the metabolism and distribution of Mg and some biochemical blood parameters in diabetic rats receiving feed containing V and Mg (MgO) [257]. 14 Mohammad A., Wang J., McNeil J.H. cibior A., Adamczyk A., Mroczka R., Niedwiecka I., Gobiowska D., Fornal E. Effects of vanadium (V) and magnesium (Mg) on rat bone tissue: mineral status and micromorphology. In this sense, our group has reported that a chimeric salt of vanadium (decavanadate-metforminium) improves glucose tolerance, lipid proles, glycogen, and triglyc-eride contents in the liver, muscle, heart, and kidney in 12). The total content of V in the organism of adults is about 100200 g (equivalent to the mean tissue concentration of about 40 nM) [6]. Vanadium: Biochemical and Molecular Biological Approaches. It eliminates the toxins and fats in the liver and makes it healthy. [152] as based on evidence from animal studies. Materials selection of optimized titanium alloys for aircraft applications. John Wiley and Sons; New York, Chichester, Weinheim, Brisbane, Singapore, Toronto: 1998. pp. Chapter 7 Bankruptcy, January 21. Effect of bis(curcumino)oxovanadium complex on non-diabetic and streptozotocin-induced diabetic rats. ). Zaporowska H., Wasilewski W. Haematological results of vanadium intoxication in Wistar rats. Thompson K.H., Lichter J., LeBel C., Scaife M.C., McNeill J.H., Orvig C. Vanadium treatment of type 2 diabetes: a view to the future. Nevertheless, no symptoms of V deficiency in humans have been described yet. 20 As reported, layers with varied composition are often applied on the surface of metallic alloys in order to improve the biological activity of the implant and provide an additional barrier against the release of metals from metallic biomaterials [11]. TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. Thus, by inhibiting RT activity, vanadium blocks viral replication. 16III). cibior A., Adamczyk A., Gobiowska D., Niedwiecka I. Metavanadate Diabetes - Crohn And Diabetes - mshale.com Altamirano-Lozano M.A., lvarez-Barrera L., Mateos-Nava R.A., Fortoul T.I., Rodrguez-Mercado J.J. National Library of Medicine In this study evaluated the effect of sodium metavanadate on glucose levels and lipid profile in type 2 diabetes mellitus patients.Methods This is a randomized, controlled trial study. beginning of this . 121133. Rehder D. The potentiality of vanadium in medicinal applications. In: Nriagu J.O., editor. Received 2019 Nov 5; Revised 2020 Feb 25; Accepted 2020 Mar 19. 6). The review paper also summarizes the available literature data on the use of V in the tissue engineering and industrial sectors with a brief description of the risk for human health. Based on available literature cited in section 9.2. Ion pumps as biological targets for decavanadate. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance but overexpression with leukocyte antygen-related phosphatase doses not additively impair insulin action. As regards V speciation, most of this metal in the liver is present in the transferrin and low-molecular mass fraction (TfF and LMMF, respectively) [108] as well as a vanadyl-ferritin [(VO2+)-FER] complex [26]. Shaik A, Kondaparthy V, Begum A, Husain A, Manwal DD. In the meantime, in 1981, the first review about the physiological and biochemical effects of V was published (Fig. Ti based biomaterials, the ultimate choice for orthopaedic implants a review. Metal based biologically active compounds: design, synthesis, and antibacterial/antifungal/cytotoxic properties of triazole-derived Schiff bases and their oxovanadium(IV) complexes. 12 Since implants made of titanium alloys (containing V) are exposed to body fluids, V may be released into surrounding tissues, exerting adverse effects. In the late 1990s, two reports described the effect of Se on V toxicity in different regions of the rat brain [267] and a synergistic interaction between V and Mg on glucose metabolism in diabetic rats [253]. Len I.E., Porro V., Di Virgilio A.L., Bollati-Fogolin M., Castelli S., Desideri A., Etcheverry S.B. Das S., Chatterjee M., Janarthan M., Ramachandran H., Chatterjee M. Vanadium in cancer prevention. Garcia L.A., Dejong S.C., Martin S.M., Smith R.S., Buettner G.R., Kerber R.E. cibior A., Zaporowska H. Effects of combined vanadate and magnesium treatment on erythrocyte antioxidant defence system in rats. cibior A., Zaporowska H., Ostrowski J., Banach A. Vanadium effects on bone metabolism. Sodium Metavanadate | AMERICAN ELEMENTS Domingo J.L., Gmez M. Vanadium compounds for the treatment of human diabetes mellitus: a scientific curiosity? government site. Interactions among the trace minerals. Noteworthy is also the fact that, through its direct influence on the organization of membrane lipids and cholesterol/sphingolipid-rich microdomains (where proteins involved in signal transduction are concentrated, e.g. cibior A., Zaporowska H. Effects of vanadium(V) and/or chromium(III) on L-ascorbic acid and glutathione as well as iron, zinc, and copper levels in rat liver and kidney. Li M., Smee J.J., Ding W., Crans D.C. Anti-diabetic effects of sodium 4-amino-2,6-dipicolinatodioxovanadium(V) dihydrate in streptozotocin-induced diabetic rats. It is known that, in some conditions, V can act as a strong pro-oxidant and interact synergistically with other oxidants enhancing oxidative stress [2,31,49], which in turn can result in many negative consequences including disintegration of cell membranes, denaturation of proteins, and degradation of DNA [50] (Fig. The interactive effects between V and Mg (studied in an animal model) have also been revealed for such parameters as V intake, V absorption, urinary and fecal V excretion, serum Mg and insulin concentration, and insulin resistance index (HOMA-IR) (Fig. Zychlinski L., Byczkowski J.Z., Kulkarni A.P. It is known that the form in which V exists in the cell depends on the ratio of the total pool of reducers to cellular oxidizers [4]. Mineral History. John Wiley and Sons; New York, Chichester, Weinheim, Brisbane, Singapore, Toronto: 1998. pp. 2022 Jan;69:126887. doi: 10.1016/j.jtemb.2021.126887. Vanadium Information | Mount Sinai - New York The mechanisms of antibacterial activity of V, which have not been fully elucidated yet, include: (a) inhibition of the activity of Na+/K+-ATPase (Fig. Majithiya J.B., Balaraman R., Giridhar R., Yadav M.R. 10 to 100 times higher than the normal intake, affect cholesterol and triglyceride metabolism, influence the erythrocyte shape, and stimulate hepatic glucose oxidation and glycogen synthesis [21]. ROS production is commonly known to lead to disturbance in cellular metabolism and damage to lysosomes and mitochondria (critical for maintaining cellular homeostasis) [148], resulting in activation of caspases and apoptosis [123,149,150]. Furthermore, vanadium has also been recognized as essential for proper growth and development of certain animals [29,35]. The final proof for the essentiality of V for humans requires confirmation of the specific function of this element, as in the case of algae or fungi. to 123, 124]. PTP1B regulates signal transduction in vivo. Shioda N., Ishigami T., Han F., Moriguchi S., Shibuya M., Iwabuchi Y., Fukunaga K. Activation of phosphatidylinositol 3-kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia. In the literature, occupational exposure to V2O5 is described as the etiological factor of the asthmatic syndrome known as "boilermaker disease" [83]. In turn, the symptoms of exposure to this metal through inhalation (illustrated in the same Figure) include rhinitis, chest pain, pharyngitis, bronchitis, pneumonia, bradycardia, cough, dyspnoea, bronchial asthma, headache, dizziness, conjunctivitis, blurred vision, apathy, and depression [9,31,81,[84], [85], [86]]. The influence of sodium metavanadate on the process of diabetogenesis As reported, the renal changes resulting from the doses used in the preclinical safety program were the cause of this decision [174] (Fig. The investigators synthesized three new complexes of this metal (at three different oxidation levels; III, IV, and V) with Schiff base ligands showing differences in the coordination of the metal with the ligand in order to compare their physicochemical and spectroscopic properties as potential antidiabetic drugs. Additionally, inhibition of biosynthesis of an important component of the fungal cell membrane, i.e. Lonard A., Gerber G.B. Accessibility 3 As presented in Fig. 3, vanadium is also a potential candidate for therapeutic applications. Vanadium is ubiquitously detected in the environment - in soil, water, and air [8]. Matsuda M., Mandarino L., DeFronzo R.A. Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats. A few years later, in 2007/08, the same V compound was used in a phase IIa trial in seven type 2 diabetic subjects [180,181] (Fig. The research on certain aspects of the biological activity of V (presented in Fig. Objective 3) to phosphate anions (PO4 The role of oxidative stress in the development of diabetes mellitus and its complications. Effects of low and high dose administration of bis(maltolato)oxovanadium(IV) on fa/fa Zucker rats. As far as application of V in diabetic patients is concerned, this may be a considerable problem and may pose a risk of toxicity, as this element is highly toxic and is able to accumulate and interact with other metals. Changes in lung function after exposure to vanadium compounds in fuel oil ash. The influence of V on bone mineralization, thyroid and erythrocyte metabolism, accumulation and transport of calcium in the cell, and the synthesis of secondary transmitters mediating in the transduction of intracellular signals is known as well. As stressed by the authors, this may point to separate metabolic pathways of these compounds in the body and a role of tridentate L Schiff base ligands. The presence of vanadium in biomedical materials requires our additional comment. Moreover, the possibility of using this metal in prevention of obesity has been suggested as well [138] (Fig. 2001. WHO: Vanadium Pentoxide and Other Inorganic Vanadium Compounds. 2V-49Co-49Fe with 2 % of V is mainly used for production of devices supporting the work of the heart (Table 2) [11]. The fact that the implant surface has a significant impact on reactions that occur at the implant-tissue interface should also be taken into account. Balance and tissue distribution of vanadium after short-term ingestion of vanadate. Toxicology of vanadium compounds in diabetic rats: the action of chelating agents on vanadium accumulation. The https:// ensures that you are connecting to the In contrast, synergistic interactions between V and Mg have been revealed for (a) the concentration of L-ascorbic acid in bone (L-AAB), (b) the activity of alkaline phosphatase (ALPB) and superoxide dismutase (SODB) in bone, (c) the concentration of calcium in erythrocytes (CaRBC) and in the liver (CaL). . Selective cytotoxicity of vanadium complexes on human pancreatic ductal adenocarcinoma cell line by inducing necroptosis, apoptosis and mitotic catastrophe process. The influence of this metal on the signaling pathway through LEP (JAK2/STAT3 pathway) [217,218] was suggested as a mechanism underlying these changes [216] (Fig. In: Fokter S., editor. Park S.J., Youn C.K., Hyun J.W., You H.J. (Vanadium in the Environment. (Metal Ions in Biological Systems). Effect of vanadate on elevate blood glucose and decreased cardiac performance of diabetic rats. Kanna P.S., Mahendrakumar C.B., Chatterjee M., Hemalatha P., Datta S., Chakraborty P. Vanadium inhibits placental glutathione S-transferase (GST-P) positive foci in 1,2-dimethyl hydrazine induced rat colon carcinogenesis. Jacques-Camarena O., Gonzlez-Ortiz M., Martnez-Abundis E., Lpez-Madrueno J.F., Medina-Santilln R. Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes: Cusi K., Cukier S., DeFronzo R.A., Torres M., Puchulu F.M., Redondo J.C.P. Sabbioni E., Rade J., Bertolero F. Relationships between iron and vanadium metabolism: the exchange of vanadium between transferrin and ferritin. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. Vanadium. For example, the mechanism by which V produces a reprotoxic effect is believed to be linked to oxidative stress [66] and/or actin cytoskeleton damage [67] (Fig. 15 11). Melechow R., Tubielewicz K., Baszczuk W. Wyd. It has been reported that V in the form of vanadyl (VO2+, tetravalent V4+ state) binds to Tf at the same binding site as the Fe3+ ion [97] and that V5+, for which the cationic form (dioxovanadium cation, VO2 In: Michibata H., editor. 710/750, May. Careers, Unable to load your collection due to an error. Vol. Webster's Revised Unabridged Dictionary, published 1913 by G. & C. Merriam Co. The research on the interactions of V with antioxidant elements has been gaining popularity since 2005. The diabetes-associated biochemical and morphological alterations in the organelle were investigated in four groups of rats: control and STZ-diabetic (C and D groups) and compared with the same groups treated with 1.5 mM metavanadate administered as drinking solutions in 0.09 M NaCl over 7 days (C+V and D+V groups). In turn, long-lasting oxidative stress with simultaneous weakening of the antioxidant system (present in every living organism) can lead to permanent cell/tissue damage and, consequently, to initiation of the disease process. Domingo J.L. The existing literature comprises a few articles about the interactions between V and Mg [[51], [52], [53],57,63,94,253,[257], [258], [259], [260]], which has been reported to be able to protect against the harmful effects of ROS [[261], [262], [263], [264]]. It is known that LPO products can stimulate the expression of oncogenes [79], which in turn can lead to transformation of normal cells into cancerous cells (Fig. Oxovanadium(IV) complexes of hydrazides: potential antifungal agents. Exposure to bis(maltolato)oxovanadium(IV) increases levels of hepcidin mRNA and impairs the homeostasis of iron but not that of manganese. cibior A. Vanadium (V) and magnesium (Mg) in vivo interactions: a review. It should also be added that more attention should be given to studies on treatment with V in association with compounds with antioxidant properties to optimize the therapeutic potential of V compounds and minimize their possible side effects. Based on available literature data cited in section 5.1 and other reports [[30], [31], [32], [33], [34]]. Geneva. [189] also used VS in NIDDM patients (Fig. For example, the results from a study conducted by Ni et al. Nogalska A., wierczyski J. Leptyna hormon o wielu funkcjach. 6 The LPL enzyme controls many metabolic processes, e.g. Gruzewska K., Michno A., Pawelczyk T., Bielarczyk H. Essentiality and toxicity of vanadium supplements in health and pathology. Evangelou A.M. Vanadium in cancer treatment. V: vanadium. Vanadium Biochemistry, Research Signpost. Differences in plasma homocysteine levels between Zucker fatty and Zucker diabetic fatty rats following 3 weeks oral administration of organic vanadium compounds. 2, February. John Wiley and Sons; New York, Chichester, Weinheim, Brisbane, Singapore, Toronto: 1998. pp. V: vanadium; Mg: magnesium, Fe: iron, Cu: copper: P: phosphorus, RBC: erythrocytes, GR: glutathione reductase, LPO: lipid peroxidation, CH: cerebral hemisphere, B: bone, WB: whole blood, L: liver, K: kidney, P: plasma, TS: transferrin saturation, L-AA: L-ascorbic acid, ALP: alkaline phosphatase, SOD: superoxide dismutase, Sa: mean roughness, Sq: root mean square roughness, Sz: ten-point height, Ins: insulin, HOMA-IR: insulin resistance index. [. Biochem. Bishayee A., Roy S., Chatterjee M. Characterization of selective induction and alteration of xenobiotic biotransforming enzymes by vanadium during diethylnitrosamine-induced chemical rat liver carcinogenesis. Domingo J.L., Gomez M., Sanchez D.J., Llobet J.M., Keen C.L. and described in the further subsections of the present report. ). ). Both sodium metavanadate and vanadyl sulfate, orally administered in doses of 50-125 mg/day for 2-4 weeks, improved fasting plasma glucose levels and daily insulin requirements in type 1 diabetes subjects. Kroniak M., Szklarzewicz J., Grybo R., Tatar B., Yildirim M., Sahin B., Yuksek N.D., Ustundag M. The influence of chronic supply of vanadium compounds on organ weights and body mass in animals diabetes model (NZO). In: Nriagu J.O., editor. Epub 2022 Jul 1. Site of vanadium inhibition of cholesterol biosynthesis. The most substantive evidence for V essentiality was found in rats and goats [after 35]. Nauk. Synergy has also been determined for such roughness parameters as (d) mean roughness (Sa) and (e) root mean square roughness (Sq) (Fig. However, there is insufficient evidence to make specific claims as to the effectiveness of gurmar at this time. Additionally, the lack of proper industrial wastewater management containing this metal can be another risk factor for animal and human health [9,82]. your password There is some evidence that high doses of vanadyl sulfate (100 mg daily, providing 31 mg elemental vanadium) might improve the way people with type 2 diabetes use insulin, the hormone that processes sugar. An official website of the United States government. cibior A., Kurus J. Vanadium and oxidative stress markers in vivo model: a review. Catal A. Lipid peroxidation of membrane phospholipids generates hydroxyl-alkenals and oxidized phospholipids active in physiological and/or pathological conditions. Braun J.E., Severson D.L. Akesis Pharmaceuticals, Inc. (in January 21, 2009) announced it has discontinued its sole clinical development program for AKP-020, a Phase IIa drug candidate for the treatment of diabetes mellitus [182]. cibior A., Adamczyk A., Gobiowska D., Kurus J. Snchez C., Torres M., Bermdez-Pea M.C., Aranda P., Montes-Bayn M., Sanz-Medel A., Llopis J. Bioavailability, tissue distribution and hypoglycaemic effect of vanadium in magnesium-deficient rats. In addition, the examination of the combined V-Mg effects in mammalian organisms may also be helpful for the future safe use of V in medicinal applications. Vanadium detoxification. Roess D.A., Smith S.M.L., Winter P., Zhou J., Dou P., Baruah B., Trujillo A.M., Levinger N.E., Yang X., Barisas B.G., Crans D.C. Insulin Receptor Substrates Regulation and Clinical Responses Following Vanadium-Enriched Yeast Supplementation in Obese Type 2 Diabetic Patients: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial. 11). nearly 150 years after the first discovery of this metal [after 38] (Fig. In: Nriagu J.O., editor. In Polish chemical literature, Radwaski described this element for the first time in 1839 giving it a Polish name "wanad", which is still used [7]. The Positive Impact of Sodium Metavanadate on Improving Health Key information about the mechanisms of the toxicity, essentiality, physiological role, and metabolism of V is collected as well along with selected aspects illustrated on the timeline. Hosseini M.J., Seyedrazi N., Shahraki J., Pourahmad J. Vanadium induces liver toxicity through reductive activation by glutathione and mitochondrial dysfunction. ). Perriello G, Misericordia P, Volpi E, Pampanelli S, Santeusanio F, Brunetti P, Bolli GB. Tolman E.L., Barris E., Burns M., Pansini A., Partridge R. Effects of vanadium on glucose metabolism in vitro. 14. Studies in non-diabetic women and in women with insulin-dependent diabetes mellitus. 289320. 11). Cholesterol levels significantly decreased in both IDDM (4.53 +/- 0.16 vs. 4.27 +/- 0.22 mmol/L; P = 0.06) and NIDDM (6.92 +/- 0.75 vs. 5.28 +/- 0.46 mmol/L; P < 0.05). 10) [39,45,[123], [124], [125], [126], [127], [128], [129]] responsible for the development of leishmaniasis and amoebiasis, respectively; (c) fungi from the genera Candida, Aspergillus, Trichophyton, and Microscopus (Fig. This is even more relevant in view of the work conducted by Wang et al. Metabolic effects of metformin on glucose and lactate metabolism in cibior A., Gobiowska D., Adamczyk A., Niedwiecka I., Fornal E. The renal effects of vanadate exposure: potential biomarkers and oxidative stress as a mechanism of functional renal disorders preliminary studies. Chakraborty T., Ghosh S., Datta S., Chakraborty P., Chatterjee M. Vanadium suppresses sister-chromatid exchange and DNA-protein crosslink formation and restores antioxidant status and hepatocellular architecture during 2-acetylaminofluorene-induced experimental rat hepatocarcinogenesis. For example, a study conducted by De la Tore et al. 11), by affecting the expression of genes involved in the synthesis of this compound [135] have been suggested. The essentiality of this element has been demonstrated for bacteria (genus Azotobacter), cyanobacteria (genera Nostoc and Anabaena), certain algae (genera Scenedesmus, Chlorella, Fucus, and Bumilleriopsis), brown algae (Ascophyllum nodosum), fungi (genera Aspergillus, Culvularia, and Amanita), and lichens [[35], [36], [37]] (Fig. Anticancer diaminotris(phenolato) vanadium(V) complexes: ligand-metal interplay. 11), with emphasis on the better bioavailability of V complexes due to the presence of a specific ligand allowing the complex to penetrate the hydrophobic lipid-rich bacteria wall [acc. J Clin Endocrinol Metab. These changes, as those mentioned previously for the liver, were also influenced by the independent action of Mg and by its antagonistic interaction with V. Moreover, the distinct trend toward the antagonistic interaction between V and Mg was revealed with regard to the level of LPO in the erythrocytes of healthy rats exposed to SMV (0.125 mg V/mL) during 12-week MS supplementation (0.06 mg Mg/mL) [53]. The other amount is mainly deposited in the liver, kidney, and spleen [108] due to the importance of these organs in detoxification of the organism and excretion of harmful substances. metal components, variations of the coordination mode, labile water molecules, and chelated ligands) probably exert an essential cooperative effect on the anti-tumor activity. cibior A., Zaporowska H., Ostrowski J. They would allow us not only to recognize a potential antidote minimizing the adverse effects of V resulting from its strong pro-oxidative activity but also to evaluate the potential efficacy of combined V-Mg treatment in certain modern-age diseases.
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